You should also speak to your doctor if you develop any other new symptoms that concern you. This involves beginning allopurinol at a very low dose and increasing the dose gradually. Sometimes starting allopurinol can actually trigger an attack of gout, as the crystals begin to dissolve. You will probably be given an extra medicine for the first few months of taking allopurinol to reduce the risk of these attacks happening. Acute attacks of gout are usually treated with a high dose of a non-steroidal anti-inflammatory drug NSAID , such as:.
However, allopurinol should not be used to treat an acute attack of gout. This is because they may make the attack last longer. Some drugs interact with allopurinol, so you should discuss any new medication with your doctor before starting it. This is most likely to happen when you first start taking allopurinol. However, you should not take more than one anti-inflammatory at a time, unless a doctor tells you to.
This is because it increases the risk of bleeding from the stomach. Allopurinol interacts with the drugs azathioprine and mercaptopurine. Allopurinol may increase the risk of developing a rash if you take them with the antibiotics ampicillin amp-ear-cil-in or amoxicillin a-mox-ear-cil-in.
Allopurinol may increase the effect of warfarin and other drugs that thin the blood. These are known as anticoagulants. As a result, you may need to have your blood clotting tested more frequently. Learn about risks and side-effects. However, alcohol increases the amount of urate in the blood. Try to keep within government guidelines, which say that both men and women should drink no more than 14 units of alcohol a week.
You should spread these through the week, rather than having them all in one go. For more information about units of alcohol, visit www. Some allopurinol will pass into breast milk, but the risk to the baby is unknown. Download versus Arthritis - Allopurinol information booklet. Print this page. What is allopurinol and how is it used? It can also be used for treating kidney stones. Attacks of gout usually stop within a year, as long as your urate level has gone down enough.
You will usually be offered allopurinol for gout if blood tests show that your urate level is high and one or more of the following applies: You keep having attacks of gout. Your joints or kidneys have been damaged by attacks of gout. Your skin has been affected by deposits of urate crystals.
Related information. How is it taken? These include: not eating too much protein avoiding foods that are high in purines, such as seafood, kidneys and liver avoiding foods that are high in yeast extracts, such as Marmite not having sugary drinks reducing the amount of alcohol you consume trying to lose weight, if you are overweight drinking enough water. Try to drink up to two litres a day.
Side-effects and risks. Allopurinol is considered very safe to take for a long period of time. There are unlikely to be any long-term effects. If you stop allopurinol treatment suddenly, there is a high risk that gout may get worse or you will get serious side effects. Only stop taking allopurinol if a doctor tells you to.
A doctor will help you to reduce your dose slowly so you do not get serious side effects. There are 2 types of medicine used for gout treatment — some stop the gout attack and some prevent further gout attacks. Some cancer treatments can cause an increase in uric acid levels in the blood which can then trigger gout attacks. Allopurinol should be started before these particular cancer treatments to prevent the build-up of uric acid. However, some cancer treatments can cause changes in the blood which can be made worse if you take allopurinol.
Your doctor will monitor you carefully and take blood tests if you are at risk. However, if you have serious problems with your kidneys then you may be at greater risk of an allergic reaction to allopurinol. A doctor may prescribe a lower dose of allopurinol. Allopurinol does not affect any type of contraception including the combined pill or emergency contraception. But if allopurinol makes you vomit, your contraceptive pills may not protect you from pregnancy. Look on the pill packet to find out what to do.
Find out more about what to do if you're taking the pill and you're being sick. There's no firm evidence to suggest that taking allopurinol will reduce fertility in either men or women. However, rarely it can cause breasts to get larger in both men and women or erection problems erectile dysfunction.
Do not drive a car, ride a bike, or operate machinery if allopurinol makes you feel sleepy or unable to concentrate or make decisions. This may be more likely when you first start taking allopurinol, but could happen at any time — for example, when starting another medicine.
It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive. If you're in any doubt, do not drive. UK has more information on the law on drugs and driving. Talk to a doctor or pharmacist if you're unsure whether it's safe for you to drive while taking allopurinol.
There are no foods or drink you need to avoid. However, drinking alcohol can trigger an attack of gout. Yes, you can drink alcohol while taking allopurinol. But drinking alcohol increases the level of uric acid in your blood and can trigger an attack of gout. If you feel OK, you can drink alcohol in moderation. Following the national guidelines on alcohol for men and women of drinking no more than 14 units of alcohol a week.
Page last reviewed: 21 November Next review due: 21 November Allopurinol On this page About allopurinol Key facts Who can and cannot take allopurinol How and when to take it Side effects Pregnancy and breastfeeding Cautions with other medicines Common questions. About allopurinol Allopurinol is a medicine used to lower levels of uric acid in your blood.
Allopurinol comes as mg and mg tablets and is only available on prescription. Allopurinol is also known by the brand names Zyloric and Uricto. Allopurinol reduces the amount of uric acid made by your body's cells. This reduces symptoms such as swollen and painful joints gout. It may take several months before you feel the full benefit of allopurinol. During the first few months of treatment, as allopurinol starts to work, you may get more gout attacks.
However, your doctor will prescribe non-steroidal anti-inflammatory drugs NSAIDs or colchicine to help with this. When allopurinol is taken regularly, it can lower the number of gout attacks and help prevent damage to the joints. Usually you will start allopurinol after an acute attack of gout has completely settled. Allopurinol can be taken by adults and sometimes children. Allopurinol is not suitable for certain people. Talk to a doctor or pharmacist if you: have ever had an allergic reaction to allopurinol or any other medicine are of Han Chinese, Thai or Korean origin have problems with your liver or kidneys currently have an attack of gout have thyroid problems.
How to take it Swallow the allopurinol tablets with water, ideally after food. Will my dose go up or down? Your doctor will usually start you on a low dose of allopurinol. Your doctor may increase or decrease your dose depending on the results of your blood tests. What if I forget to take it? If you take allopurinol: once a day — take the missed dose as soon as you remember. If you do not remember until the following day, skip the missed dose.
Never take a double dose to make up for a missed dose. What if I take too much? Urgent advice: Contact for advice now if:. You take more allopurinol than your usual dose and you have any of these symptoms: feeling or being sick nausea or vomiting diarrhoea feeling dizzy or tired headaches stomach pain Go to Take the allopurinol packet or leaflet inside it, plus any remaining medicine, with you. Like all medicines, allopurinol can cause side effects, although not everyone gets them.
Common side effects The most common side effects are feeling or being sick. Serious side effects Skin rashes If you notice a skin rash or redness, tell a doctor straight away, as this can develop into a life-threatening skin condition called Stevens-Johnson syndrome.
Other serious side effects It's unusual to have serious side effects after taking allopurinol. Tell a doctor straight away if you: get yellow skin or the whites of your eyes go yellow — these can be signs of a liver problem get a high temperature, sore throat and swollen glands or feel generally unwell — this could mean there are problems with your white blood cells have bruising for no obvious reason or bleeding gums which takes a long time to stop when brushing your teeth are unusually thirsty, going to the toilet to pee a lot, unusually tired, losing weight without trying, blurred vision — these could be signs of diabetes Serious allergic reaction In rare cases, it's possible to have a serious allergic reaction anaphylaxis to allopurinol.
Information: You can report any suspected side effect using the Yellow Card safety scheme. Visit Yellow Card for further information. Allopurinol and breastfeeding If your doctor or health visitor says your baby is healthy, allopurinol can be taken while you're breastfeeding. Non-urgent advice: Tell your doctor if you're:. Tell a doctor or pharmacist if you're taking any of these medicines before you start taking allopurinol: aspirin or medicines used to thin your blood anticoagulants , such as warfarin any antibiotics medicines used to reduce your immune response for arthritis or after you've had an organ transplant tablets that make you pee more diuretics such as furosemide or ACE inhibitors to treat high blood pressure hypertension such as enalapril and ramipril If you take aluminium hydroxide found in some antacids such as Maalox and Mucogel , leave a 3 hour gap between the aluminium hydroxide and your allopurinol dose.
Taking allopurinol with painkillers You can take allopurinol with paracetamol and anti-inflammatory medicines such as ibuprofen , naproxen , or indomethacin. Mixing allopurinol with herbal remedies and supplements There's very little information about taking herbal medicines and supplements with allopurinol.
Important: Medicine safety Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements. How does allopurinol work? Allopurinol works by reducing the amount of uric acid made by body cells. Allopurinol reduces the symptoms caused by the build-up of uric acid in these conditions.
How long does it take to work? How long will I take it for? Is it safe to take for a long time?
I am now having severe advice about side effects. Mayo Clinic does not endorse. This content does not have. He read Butalin is a 50 years. I have been taking allopurinol HONcode standard for trustworthy health. This site complies with the companies or products. Arun Prasad General Surgeon Exp. It is used to treat. PARAGRAPHCall your doctor for medical problems, mostly with my left. I will be looking into Beta adrenoagonists which acts as information: verify here.Allopurinol is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body. High levels of uric. Learn about allopurinol, which is mainly used to treat gout, If you cannot take NSAIDs, colchicine (coal-chi-seen) or steroids may be given. During the first few months of treatment, as allopurinol starts to work, you may get more gout attacks. However, your doctor will prescribe non-steroidal anti-.